An MLL-SEPT9 fusion and t(11;17)(q23;q25) associated with de novo myelodysplastic syndrome
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چکیده
منابع مشابه
Cryptic e1a2 BCR-ABL1 Fusion With Complex Chromosomal Abnormality in de novo Myelodysplastic Syndrome
Bo-Young Seo, M.D., Jun-Hyoung Lee, M.D., Min-Gu Kang, M.D., Seok-Yong Choi, M.D., Soo-Hyun Kim, M.D., Jong-Hee Shin, M.D., Soon-Pal Suh, M.D., Dong-Wook Ryang, M.D., and Myung-Geun Shin, M.D. Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun; Environmental Health Center for Childhood Leukemia and Cancer, Chonna...
متن کاملCytogenetic profile of Indian patients with de novo myelodysplastic syndromes
BACKGROUND & OBJECTIVES Myelodysplastic syndrome (MDS) is a clonal haematopoietic stem cell disorder characterized by ineffective haematopoiesis and leukaemia progression. Cytogenetic analysis has proven to be a mandatory part of the diagnosis of MDS as well as a major indicator for predicting clinical course and outcome. Studies on cytogenetics of MDS are reported mostly from the West and only...
متن کاملAbrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22).
The disruption of RUNX1 function is one of the main mechanisms of disease observed in hematopoietic malignancies and the description of novel genetic events that lead to a RUNX1 loss of function has been accelerated with the development of genomic technologies. Here we describe the molecular characterization of a new t(4;21)(q21;q22) in a de novo myelodysplastic syndrome that resulted in the de...
متن کاملSpontaneous remission in adult patients with de novo myelodysplastic syndrome: a possible event.
BACKGROUND AND OBJECTIVES Spontaneous remission (SR) in de novo myelodysplastic syndromes (MDS) is a rare event, which has been so far described only in children with monosomy 7. The phenomenon is extremely heterogeneous, perhaps depending on different pathogeneses of the disease. DESIGN AND METHODS We retrospectively evaluated the outcome of 564 consecutive adult patients with primary MDS di...
متن کاملDe-Novo Presentation of Histoid Leprosy on an Unusual Site
Histoid Leprosy (HL) is a rare variant of Lepromatous Leprosy, occurring in long-standing cases, mostly in a background of acquired drug resistance. Patients usually present with sudden onset multiple nodules and plaques, most often involving the skin and subcutaneous tissue of trunk and lower limbs. Here we report an unusual case of de novo (without any history of prior anti-leprotic therapy) ...
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ژورنال
عنوان ژورنال: Leukemia Research
سال: 2007
ISSN: 0145-2126
DOI: 10.1016/j.leukres.2006.12.006